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Article

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.

Nature genetics - 1 Sept 2014

Gross Andrew M, Orosco Ryan K, Shen John P, Egloff Ann Marie, Carter Hannah, Hofree Matan, Choueiri Michel, Coffey Charles S, Lippman Scott M, Hayes D Neil, Cohen Ezra E, Grandis Jennifer R, Nguyen Quyen T, Ideker Trey

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a propensity for metastasis and recurrence. Here we report a comprehensive analysis of the molecular and clinical features of HNSCC that govern patient survival. We find that TP53 mutation is frequently accompanied by loss of chromosome 3p and that the combination of these events is associated with a surprising decrease in...

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Share to Carcinoma, Squamous Cell
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 3

Share to Genes, p53

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Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 25086664
DOI: 10.1038/ng.3051
PMCID: PMC4146706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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