Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma.

BMC cancer - 16 Sept 2021

Shi Congyu, Liu Shan, Tian Xudong, Wang Xiaoyi, Gao Pan

Abstract excerpt

BACKGROUND: Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established a TP53 mutation associated risk score model to evaluate the prognosis and therapeutic responses of patients with HNSC. METHODS: Differentially expressed genes between patients with and without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Genes, p53
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Checkpoint Inhibitors

Share to Kaplan-Meier Estimate

Share to Proportional Hazards Models

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34530752
DOI: 10.1186/s12885-021-08765-w
PMCID: PMC8447564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma.PMID 34530752Read ↗

Significance of TP53 mutation in treatment and prognosis in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.Semantic proximity Read ↗

Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell CancerSemantic proximity Read ↗

TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Semantic proximity Read ↗

High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma.Semantic proximity Read ↗

Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients.Semantic proximity Read ↗

Predicting therapeutic responses in head and neck squamous cell carcinoma from TP53 mutation and The mutation of TP53 could be detected by cfDNASemantic proximity Read ↗

TP53 mutations in head and neck cancer.Semantic proximity Read ↗

Pinpointing the decisive role of TP53 mutations in orchestrating immunosuppression in head and neck squamous cell carcinomaSemantic proximity Read ↗

Tumor Mutation Burden, Immune Cell Infiltration, and Construction of Immune-Related Genes Prognostic Model in Head and Neck Cancer.Semantic proximity Read ↗

Integrative analysis of TP53 mutations in lung adenocarcinoma for immunotherapies and prognosis.Semantic proximity Read ↗

CD8 + T cell related prognostic risk model and tumor immune environment modulation in HNSCC based on single-cell and bulk RNA sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.