Article
Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.
Cancer research - 1 Oct 2020
Park Dongju, Bergin Stephen M, Jones Dan, Ru Peng, Koivisto Christopher S, Jeon Young-Jun, Sizemore Gina M, Kladney Raleigh D, Hadjis Ashley, Shakya Reena, Ludwig Thomas
Abstract excerpt
Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers, and hypersensitivity to DNA-crosslinking agents. BRCA1 is critical for homologous recombination of DNA double-strand breaks (DSB)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.