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Article

PALB2/FANCN: recombining cancer and Fanconi anemia.

Cancer research - 1 Oct 2010

Tischkowitz Marc, Xia Bing

Abstract excerpt

Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became clear that PALB2 was another Fanconi anemia (FA) gene (FANCN), and that monoallelic PALB2 mutations are associated with increased risk of breast and pancreatic cancer. Mutations in PALB2 have been identified in breast cancer families...

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Topics

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Share to Fanconi Anemia
Share to Fanconi Anemia Complementation Group N Protein
Share to BRCA2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20858716
DOI: 10.1158/0008-5472.CAN-10-1012
PMCID: PMC2948578

Genes

PALB2
BRCA2
BRCA1

Provenance

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PALB2/FANCN: recombining cancer and Fanconi anemia.PMID 20858716Read ↗

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.Semantic proximity Read ↗

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.Semantic proximity Read ↗

PALB2 links BRCA1 and BRCA2 in the DNA-damage response.Semantic proximity Read ↗

The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Semantic proximity Read ↗

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.Semantic proximity Read ↗

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.Semantic proximity Read ↗

Integrated Bioinformatics Analysis of PALB2 Reveals Expression Patterns, Molecular Interactions, and Prognostic Significance in Breast CancerSemantic proximity Read ↗

Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.Semantic proximity Read ↗

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.Semantic proximity Read ↗

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.Semantic proximity Read ↗

Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.Semantic proximity Read ↗

Novel strand exchange activity of the human PALB2 DNA Binding Domain and its critical role for DNA repair in cellsSemantic proximity Read ↗

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