Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defects in homologous recombination repair behind the human diseases: FA and HBOC

22 Aug 2016

Abstract excerpt

Hereditary breast and ovarian cancer (HBOC) syndrome and a rare childhood disorder Fanconi anemia (FA) are caused by homologous recombination (HR) defects, and some of the causative genes overlap. Recent studies in this field have led to the exciting development of PARP inhibitors as novel cancer therapeutics and have clarified important mechanisms underlying genome instability and tumor suppression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27550963
DOI: 10.1530/erc-16-0221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in homologous recombination repair behind the human diseases: FA and HBOCPMID 27550963Read ↗

Hereditary Breast and Ovarian Cancer Syndrome: Moving Beyond BRCA1 and BRCA2Semantic proximity Read ↗

Homologous repair of DNA damage and tumorigenesis: the BRCA connection.Semantic proximity Read ↗

Genetic Basis of Breast and Ovarian Cancer: Approaches and Lessons Learnt from Three Decades of Inherited Predisposition TestingSemantic proximity Read ↗

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.Semantic proximity Read ↗

Homologous Recombination Deficiencies and Hereditary Tumors.Semantic proximity Read ↗

Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and CancerSemantic proximity Read ↗

Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision OncologySemantic proximity Read ↗

Comprehensive review on Fanconi anemia: insights into DNA interstrand cross-links, repair pathways, and associated tumorsSemantic proximity Read ↗

The Fanconi anemia pathway and Breast Cancer: A comprehensive review of clinical data.Semantic proximity Read ↗

Beyond BRCA: Discovery of novel causes and consequences of homologous recombination deficienciesSemantic proximity Read ↗

Homologous Recombination Defects and Mutations in DNA Damage Response (DDR) Genes Besides BRCA1 and BRCA2 as Breast Cancer Biomarkers for PARP Inhibitors and Other DDR Targeting Therapies.Semantic proximity Read ↗

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.