Article
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.
Future oncology (London, England) - 1 Feb 2011
Cantor Sharon B, Guillemette Shawna
Abstract excerpt
It is clear that FANCJ, also known as BACH1 or BRIP1, is an essential tumor suppressor gene based on the identification of clinically relevant mutations not only in breast cancer, but also the childhood cancer syndrome, Fanconi anemia. This conclusion is further supported by the direct and functional interaction between FANCJ and the hereditary breast cancer-associated gene product BRCA1. In the absence of the...
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