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Article

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.

PLoS genetics - 1 Aug 2016

Hartford Suzanne A, Chittela Rajanikant, Ding Xia, Vyas Aradhana, Martin Betty, Burkett Sandra, Haines Diana C, Southon Eileen, Tessarollo Lino, Sharan Shyam K

Abstract excerpt

Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that is essential for maintaining genomic integrity. Among the proteins that physically interact with BRCA2, Partner and Localizer of BRCA2 (PALB2), which binds to the N-terminal region of BRCA2, is vital for its function by facilitating its subnuclear localization. A functional redundancy has been reported between this N-terminal...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Breaks, Double-Stranded

Share to Fanconi Anemia Complementation Group N Protein

Share to Gene Knock-In Techniques

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Source

Open in PubMed Open full text

Identifiers

PMID: 27490902
DOI: 10.1371/journal.pgen.1006236
PMCID: PMC4973925

Genes

BRCA2
PALB2

Provenance

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Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.PMID 27490902Read ↗

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Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.Semantic proximity Read ↗

Molding BRCA2 function through its interacting partners.Semantic proximity Read ↗

Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.Semantic proximity Read ↗

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