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Article

Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers.

International journal of hematology - 1 Sept 2017

Cheung Ronald S, Taniguchi Toshiyasu

Abstract excerpt

Fanconi anemia (FA), the most common form of inherited bone marrow failure, predisposes to leukemia and solid tumors. FA is caused by the genetic disruption of a cellular pathway that repairs DNA interstrand crosslinks. The impaired function of this pathway, and the genetic instability that results, is considered the main pathogenic mechanism behind this disease. The identification of breast cancer susceptibility...

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Identifiers

PMID: 28631178
DOI: 10.1007/s12185-017-2283-4
PMCID: PMC5904331

Genes

BRCA1
BRCA2

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