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<i>Palb2</i> synergizes with <i>Trp53</i> to suppress mammary tumor formation in a model of inherited breast cancer

8 May 2013

Abstract excerpt

Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous recombination-type double strand break repair (HR-DSBR) through physical interactions with BRCA1, BRCA2, and RAD51. To further understand the mechanisms underlying PALB2-mediated DNA repair and tumor...

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PMID: 23657012
DOI: 10.1073/pnas.1305362110

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<i>Palb2</i> synergizes with <i>Trp53</i> to suppress mammary tumor formation in a model of inherited breast cancerPMID 23657012Read ↗

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