Article
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
Nature metabolism - 1 Sept 2020
Pinkosky Stephen L, Scott John W, Desjardins Eric M, Smith Brennan K, Day Emily A, Ford Rebecca J, Langendorf Christopher G, Ling Naomi X Y, Nero Tracy L, Loh Kim, Galic Sandra, Hoque Ashfaqul, Smiles William J, Ngoei Kevin R W, Parker Michael W, Yan Yan, Melcher Karsten, Kemp Bruce E, Oakhill Jonathan S, Steinberg Gregory R
Abstract excerpt
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA and relieves inhibition of carnitine palmitoyl-transferase 1, thereby promoting LCFA-CoA transport into the...
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