Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

The Journal of biological chemistry - 9 Nov 2007

Sanders Matthew J, Ali Zahabia S, Hegarty Bronwyn D, Heath Richard, Snowden Michael A, Carling David

Abstract excerpt

AMP-activated protein kinase (AMPK) plays a key role in maintaining energy homeostasis. Activation of AMPK in peripheral tissues has been shown to alleviate the symptoms of metabolic diseases, such as type 2 diabetes, and consequently AMPK is a target for treatment of these diseases. Recently, a small molecule activator (A-769662) of AMPK was identified that had beneficial effects on metabolism in ob/ob mice....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Biphenyl Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multienzyme Complexes

Share to Protein Subunits

Share to Pyridines

Share to Pyrones

Share to Thiophenes

Share to Threonine

Source

Identifiers

PMID: 17728241
DOI: 10.1074/jbc.M706543200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.PMID 17728241Read ↗

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read ↗

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.Semantic proximity Read ↗

Investigating the regulation of AMP-activated protein kinaseSemantic proximity Read ↗

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827Semantic proximity Read ↗

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.Semantic proximity Read ↗

Advances in the research of AMPK and its subunit genes.Semantic proximity Read ↗

The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletionSemantic proximity Read ↗

Direct β1/ β2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitisSemantic proximity Read ↗

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.Semantic proximity Read ↗

Acute, next‐generation AMPK activation initiates a disease‐resistant gene expression program in dystrophic skeletal muscleSemantic proximity Read ↗

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?Semantic proximity Read ↗

Metabolic functions of AMPK: aspects of structure and of natural mutations in the regulatory gamma subunits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.