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A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes.

Human molecular genetics - 1 Oct 2018

Boufroura Fatima-Zohra, Le Bachelier Carole, Tomkiewicz-Raulet Céline, Schlemmer Dimitri, Benoist Jean-François, Grondin Pascal, Lamotte Yann, Mirguet Olivier, Mouillet-Richard Sophie, Bastin Jean, Djouadi Fatima

Abstract excerpt

Carnitine palmitoyl transferase 2 (CPT2) deficiency is one of the most common inherited fatty acid oxidation (FAO) defects and represents a prototypical mitochondrial metabolic myopathy. Recent studies have suggested a pivotal role of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle plasticity and mitochondrial homeostasis. Thus, we tested the potential of GSK773, a novel direct AMPK...

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Share to AMP-Activated Protein Kinase Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30007356
DOI: 10.1093/hmg/ddy254

Genes

CPT2

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