Article
Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements.
Nature microbiology - 1 Nov 2020
Frazer Corey, Staples Mae I, Kim Yoori, Hirakawa Matthew, Dowell Maureen A, Johnson Nicole V, Hernday Aaron D, Ryan Veronica H, Fawzi Nicolas L, Finkelstein Ilya J, Bennett Richard J
Abstract excerpt
Cell identity in eukaryotes is controlled by transcriptional regulatory networks that define cell-type-specific gene expression. In the opportunistic fungal pathogen Candida albicans, transcriptional regulatory networks regulate epigenetic switching between two alternative cell states, 'white' and 'opaque', that exhibit distinct host interactions. In the present study, we reveal that the transcription factors...
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