Article
Trajectory analysis quantifies transcriptional plasticity during macrophage polarization.
Scientific reports - 23 Jul 2020
Liu Serena X, Gustafson Heather H, Jackson Dana L, Pun Suzie H, Trapnell Cole
Abstract excerpt
In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages retain any persistent memory of past polarization states which may then impact their future repolarization to new states. Here, we perform deep transcriptomic profiling at high temporal resolution as macrophages are polarized with cytokines that drive them...
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