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Article

Does tissue imprinting restrict macrophage plasticity?

Nature immunology - 1 Feb 2021

Guilliams Martin, Svedberg Freya R

Abstract excerpt

Macrophages have long been considered as particularly plastic cells. However, recent work combining fate mapping, single-cell transcriptomics and epigenetics has undermined the macrophage plasticity dogma. Here, we discuss recent studies that have carefully dissected the response of individual macrophage subsets to pulmonary insults and call for an adjustment of the macrophage plasticity concept. We hypothesize...

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Share to Cell Plasticity
Share to Cellular Microenvironment
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Macrophages, Alveolar

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Identifiers

PMID: 33462453
DOI: 10.1038/s41590-020-00849-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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