Article
A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology.
PLoS computational biology - 1 Nov 2019
Zhao Chen, Mirando Adam C, Sové Richard J, Medeiros Thalyta X, Annex Brian H, Popel Aleksander S
Abstract excerpt
Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they acquire different patterns of transcriptional activation, cytokine expression and cellular metabolism which collectively constitute a continuous spectrum of phenotypes, of which the two extremes are denoted as classical (M1) and alternative (M2)...
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