Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells

Abstract excerpt

Accumulation of senescent cells in tissues during normal or accelerated aging has been shown to be detrimental and to favor the outcomes of age-related diseases such as heart failure (HF). We have previously shown that oxidative stress dependent on monoamine oxidase A (MAOA) activity in cardiomyocytes promotes mitochondrial damage, the formation of telomere-associated foci, senescence markers, and triggers...

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• Share to Mitochondrial Function and Pathology
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Telomeres, Telomerase, and Senescence