Article

Cholesterol Alters Mitophagy By Impairing Optineurin Recruitment And Lysosomal Clearance In Alzheimer’s Disease

2021-02-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer’s disease (AD) pathogenesis. Amyloid-beta (Ab) metabolism and the microtubule-associated protein tau have been reported to regulate key components of the mitophagy machinery. However, the mechanisms that lead to mitophagy dysfunction...

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Literature Corpus work: e19c905f-3073-5a22-adbe-390caf65cd2d
DOI: 10.21203/rs.3.rs-69969/v3

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