Article

Myeloid STING restrains cardiac remodeling by suppressing macrophage amyloid precursor protein

2026-07-03

Abstract excerpt

Mitochondrial DNA (mtDNA) released into the cytosol activates innate immune signaling and promotes inflammation, yet its role in macrophages following sterile tissue injury remains poorly understood. Here, we show that cardiac macrophages from both patients and mice with myocardial infarction (MI) exhibit increased mitochondrial biogenesis, mitochondrial content, membrane potential, and expression of mitochondrial...

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Literature Corpus work: 8585f316-77f7-511f-a460-94ec33ff432f
DOI: 10.64898/2026.07.01.735895

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