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MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and PI3K-Akt-ROS pathway.

2024-07-22

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) stands as one of the prevalent irreversible neurodegenerative conditions marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)-Hippo pathway is pivotal in regulating cell apoptosis, immune response, mitochondrial function, and oxidative stress. However, the association between MST1 and mitochondrial funct...

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Literature Corpus work
c93a3387-e079-50a0-b241-9dd23cdeff82
DOI
10.21203/rs.3.rs-4610030/v1
Open publication

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MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and PI3K-Akt-ROS pathway.DOI 10.21203/rs.3.rs-4610030/v1
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