Article

Would It Be Possible to Stabilize Prefusion SARS-COV-2 Spikes with Ligands?

2021-06-08

Abstract excerpt

Fusion to host cells and infection caused by Severe Acute Respiratory Syndrome coronavirus (SARS)-CoV2 was inhibited in vitro by PP mutations stabilizing prefusion states of their spike (S) protein native conformation, as reported by several authors. However, the possible stabilization of S by binding-ligands, rather than by mutations, have not been explored, nor it is yet known if it would be possible. In...

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Literature Corpus work: 4bf25547-0ceb-5efb-8494-95291d272cb5
DOI: 10.26434/chemrxiv.13453919.v2

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