Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance).

doi:10.1016/j.jns.2015.06.056

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Article

Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance).

Journal of the neurological sciences - 15 Oct 2015

Boora Ganesh K, Kulkarni Amit A, Kanwar Rahul, Beyerlein Peter, Qin Rui, Banck Michaela S, Ruddy Kathryn J, Pleticha Josef, Lynch Cynthia A, Behrens Robert J, Züchner Stephan, Loprinzi Charles L, Beutler Andreas S

Abstract excerpt

The predisposition of patients to develop polyneuropathy in response to toxic exposure may have a genetic basis. The previous study Alliance N08C1 found an association of the Charcot-Marie-Tooth disease (CMT) gene ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy (CIPN) related to the three non-synonymous, recurrent single nucleotide variants (SNV), whereby rs9657362 had the strongest effect,...

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Identifiers

PMID: 26143528
DOI: 10.1016/j.jns.2015.06.056
PMCID: PMC4575633

Genes

ARHGEF10

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