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Article

BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2020

Kitson Sarah J, Bafligil Cemsel, Ryan Neil A J, Lalloo Fiona, Woodward Emma R, Clayton Richard D, Edmondson Richard J, Bolton James, Crosbie Emma J, Evans D Gareth

Abstract excerpt

BACKGROUND: An association between BRCA pathogenic variants and an increased endometrial cancer risk, specifically serous-like endometrial cancer, has been postulated but remains unproven, particularly for BRCA2 carriers. Mechanistic evidence is lacking, and any link may be related to tamoxifen exposure or testing bias. Hysterectomy during risk-reducing bilateral salpingo-oophorectomy is, therefore, of uncertain...

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Identifiers

PMID: 32698099
DOI: 10.1016/j.ejca.2020.05.030
PMCID: PMC7441309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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