Article
Incidence of endometrial cancer in BRCA mutation carriers.
Gynecologic oncology - 1 Oct 2024
Kotsopoulos Joanne, Lubinski Jan, Huzarski Tomasz, Bychkovsky Brittany L, Moller Pal, Kim Raymond H, Tung Nadine, Eisen Andrea, Foulkes William, Singer Christian F, Aeilts Amber, Neuhausen Susan L, Bordeleau Louise, Karlan Beth, Fruscio Robert, Eng Charis, Olopade Olufunmilayo, Zakalik Dana, Couch Fergus, Y Cajal Teresa Ramon, Sun Ping, Gronwald Jacek, Narod Steven A
Abstract excerpt
OBJECTIVE: Whether or not women who harbor a germline pathogenic variant ('mutation') in the BRCA1 or BRCA2 genes are at elevated risk of developing endometrial cancer is yet to be determined. METHODS: We conducted a prospective analysis of 4959 BRCA mutation carriers with no prior history of cancer (except for breast or melanoma) and an intact uterus. RESULTS: After a mean of 6.7 years of follow-up there were 38...
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