Article
Specialist oncological surgery for removal of the ovaries and fallopian tubes in BRCA1 and BRCA2 pathogenic variant carriers may reduce primary peritoneal cancer risk to very low levels.
International journal of cancer - 1 Mar 2021
Crosbie Emma J, Flaum Nicola, Harkness Elaine F, Clayton Richard D, Holland Cathrine, Martin-Hirsch Pierre, Wood Nick, Keating Patrick, Woodward Emma R, Lalloo Fiona, Donnai Paul, Edmondson Richard J, Evans D Gareth
Abstract excerpt
Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is highly effective for the prevention of high-grade serous ovarian cancer (HGSOC) in BRCA1/2 pathogenic variant carriers (PVCs), but does not completely eliminate future risk of primary peritoneal cancer (PPC). The requirement to completely remove fallopian tubes at RRBSO and carefully exclude occult cancer/serous tubal intraepithelial carcinoma (STIC)...
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