Article
Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations.
JAMA oncology - 1 Nov 2016
Shu Catherine A, Pike Malcolm C, Jotwani Anjali R, Friebel Tara M, Soslow Robert A, Levine Douglas A, Nathanson Katherine L, Konner Jason A, Arnold Angela G, Bogomolniy Faina, Dao Fanny, Olvera Narciso, Bancroft Elizabeth K, Goldfrank Deborah J, Stadler Zsofia K, Robson Mark E, Brown Carol L, Leitao Mario M, Abu-Rustum Nadeem R, Aghajanian Carol A, Blum Joanne L, Neuhausen Susan L, Garber Judy E, Daly Mary B, Isaacs Claudine, Eeles Rosalind A, Ganz Patricia A, Barakat Richard R, Offit Kenneth, Domchek Susan M, Rebbeck Timothy R, Kauff Noah D
Abstract excerpt
IMPORTANCE: The link between BRCA mutations and uterine cancer is unclear. Therefore, although risk-reducing salpingo-oophorectomy (RRSO) is standard treatment among women with BRCA mutations (BRCA+ women), the role of concomitant hysterectomy is controversial. OBJECTIVE: To determine the risk for uterine cancer and distribution of specific histologic subtypes in BRCA+ women after RRSO without hysterectomy....
Topics
- Adult
- Female
- Follow-Up Studies
- Genes, BRCA1
- Genes, BRCA2
- Humans
- Hysterectomy
- Loss of Heterozygosity