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Endometrial Cancer in Germline BRCA Mutation Carriers: A Systematic Review and Meta-analysis.

Journal of minimally invasive gynecology - 1 May 2021

Matanes Emad, Volodarsky-Perel Alexander, Eisenberg Neta, Rottenstreich Misgav, Yasmeen Amber, Mitric Cristina, Lau Susie, Salvador Shannon, Gotlieb Walter H, Kogan Liron

Abstract excerpt

OBJECTIVE: Risk-reducing salpingo-oophorectomy (RRSO) is standard treatment among women with BRCA mutations. The aim of this meta-analysis is to evaluate the risk of endometrial cancer (EC) in BRCA1 or BRCA2 germline mutation carriers and to examine the justifiability of prophylactic hysterectomy at the time of RRSO. DATA SOURCES: PubMed, Cochrane Central Register of Controlled Trials, BIOSIS, Medline (Ovid), Web...

Topics

BRCA2 Protein
Breast Neoplasms
Endometrial Neoplasms
Female
Genes, BRCA2
Genetic Predisposition to Disease
Germ Cells
Germ-Line Mutation
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovarian Neoplasms

Ovariectomy

Source

Identifiers

PMID: 33249269
DOI: 10.1016/j.jmig.2020.11.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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