Article
Risk of Serous Endometrial Carcinoma in Women With Pathogenic BRCA1/2 Variant After Risk-Reducing Salpingo-Oophorectomy.
Journal of the National Cancer Institute - 1 Feb 2018
Saule Claire, Mouret-Fourme Emmanuelle, Briaux Adrien, Becette Véronique, Rouzier Roman, Houdayer Claude, Stoppa-Lyonnet Dominique
Abstract excerpt
It has recently been shown that the risk of a rare subtype of endometrial carcinoma (serous type) in women carrying a germline BRCA1/2 pathogenic variant is increased. We assessed the incidence of serous endometrial carcinoma in an independent prospective cohort study of 369 BRCA1/2 women (1779 woman-years of follow-up) who underwent risk-reducing salpingo-oophorectomy by laparoscopy. This occurrence in two BRCA1...
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