Article
Endometrial Cancer Risk in Women With Germline BRCA1 or BRCA2 Mutations: Multicenter Cohort Study.
Journal of the National Cancer Institute - 4 Sept 2021
de Jonge Marthe M, de Kroon Cornelis D, Jenner Denise J, Oosting Jan, de Hullu Joanne A, Mourits Marian J E, Gómez Garcia Encarna B, Ausems Margreet G E M, Margriet Collée J, van Engelen Klaartje, van de Beek Irma, Smit Vincent T H B M, Rookus Matti A, de Bock Geertruida H, van Leeuwen Flora E, Bosse Tjalling, Dekkers Olaf M, van Asperen Christi J
Abstract excerpt
BACKGROUND: Endometrial cancer (EC) risk in BReast CAncer gene 1/2 (BRCA1/2) mutation carriers is uncertain; therefore, we assessed this in a large Dutch nationwide cohort study. METHODS: We selected 5980 BRCA1/2 (3788 BRCA1, 2151 gBRCA2, 41 both BRCA1/BRCA2) and 8451 non-BRCA1/2 mutation carriers from the Hereditary Breast and Ovarian cancer study, the Netherlands cohort. Follow-up started at the date of the...
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