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Article

Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines.

British journal of cancer - 1 Aug 2023

McCarthy Rebecca L, Copson Ellen, Tapper William, Bolton Helen, Mirnezami Alex H, O'Neill J Robert, Patel Nimesh N, Tischkowitz Marc, Cutress Ramsey I

Abstract excerpt

Identifying healthy carriers of germline pathogenic variants in high penetrance cancer susceptibility genes offers the potential for risk-reducing surgery. The NHS England National Genomic Test Directory offers germline and somatic testing to patients with certain cancers or rare and inherited diseases, or, in some cases, to their relatives. This review summarises current UK guidelines for risk-reducing surgical...

Topics

Female
Humans
Breast Neoplasms
Mastectomy
Germ-Line Mutation
Genetic Testing
United Kingdom
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37258796
DOI: 10.1038/s41416-023-02296-w
PMCID: PMC10403612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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