Article
Risk of uterine cancer for BRCA1 and BRCA2 mutation carriers.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2017
Lee Y C, Milne R L, Lheureux S, Friedlander M, McLachlan S A, Martin K L, Bernardini M Q, Smith C, Picken S, Nesci S, Hopper J L, Phillips K A
Abstract excerpt
BACKGROUND: Whether BRCA1 and BRCA2 mutation carriers have a clinically relevant elevated risk of uterine cancer has implications for risk-reducing surgery. AIM: This multicentre, prospective cohort study assessed uterine cancer risk for mutation carriers compared with the general population. METHODS: Eligible mutation carriers were enrolled in the Kathleen Cuningham Foundation Consortium for Research into...
Topics
- Adult
- Australia
- BRCA1 Protein
- BRCA2 Protein
- Biomarkers, Tumor
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Hysterectomy