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Article

Suppression of premature termination codons as a therapeutic approach.

Critical reviews in biochemistry and molecular biology - 1 Sept 2012

Keeling Kim M, Wang Dan, Conard Sara E, Bedwell David M

Abstract excerpt

In this review, we describe our current understanding of translation termination and pharmacological agents that influence the accuracy of this process. A number of drugs have been identified that induce suppression of translation termination at in-frame premature termination codons (PTCs; also known as nonsense mutations) in mammalian cells. We discuss efforts to utilize these drugs to suppress disease-causing...

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Identifiers

PMID: 22672057
DOI: 10.3109/10409238.2012.694846
PMCID: PMC3432268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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