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Article

Adipokine apelin ameliorates chronic colitis in Il-10-/- mice by promoting intestinal lymphatic functions.

Biochemical pharmacology - 1 Feb 2018

Ge Yuanyuan, Li Yi, Chen Qin, Zhu Weiming, Zuo Lugen, Guo Zhen, Gong Jianfeng, Cao Lei, Gu Lili, Li Jieshou

Abstract excerpt

Both mesenteric adipose tissue (MAT) and lymphatic vessels (LVs) play important roles in the pathogenesis of Crohn's disease (CD), and adipokines have been implicated in the crosstalk between MAT and LVs. Apelin, a newly identified adipokine, has been demonstrated to be crucial in the development and stabilization of LVs. We aimed to identify the expression of apelin in MAT of CD patients and explore whether...

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PMID: 29309764
DOI: 10.1016/j.bcp.2018.01.011

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