Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.

doi:10.1038/s41467-019-13559-7

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Article

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.

Nature communications - 10 Dec 2019

Ziegler Jörn F, Böttcher Chotima, Letizia Marilena, Yerinde Cansu, Wu Hao, Freise Inka, Rodriguez-Sillke Yasmina, Stoyanova Ani K, Kreis Martin E, Asbach Patrick, Kunkel Desiree, Priller Josef, Anagnostopoulos Ioannis, Kühl Anja A, Miehle Konstanze, Stumvoll Michael, Tran Florian, Fredrich Broder, Forster Michael, Franke Andre, Bojarski Christian, Glauben Rainer, Löscher Britt-Sabina, Siegmund Britta, Weidinger Carl

Abstract excerpt

Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn's disease remains sparse. We here describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn's disease (AGLCD) featuring a lack of adipose tissue, leptin deficiency and intestinal inflammation. Using mass and flow cytometry,...

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Identifiers

PMID: 31822667
DOI: 10.1038/s41467-019-13559-7
PMCID: PMC6904732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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