Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using non-coding small RNAs to develop therapies for Huntington's disease.

Gene therapy - 1 Dec 2011

Zhang Y, Friedlander R M

Abstract excerpt

Huntington's disease (HD) is caused by an expansion of CAG triplets at the 5' end of the HD gene, which encodes a pathologically elongated polyglutamine stretch near the N-terminus of huntingtin. HD is an incurable autosomal-dominant neurodegenerative disease characterized by movement disorder, as well as emotional distress and dementia. The newly discovered roles of the non-coding small RNAs in specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Delivery Systems
Share to Huntingtin Protein
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Tissue Proteins

Share to Nuclear Proteins

Share to RNA Interference

Share to RNA, Small Interfering

Share to RNA, Small Untranslated

Source

Identifiers

PMID: 22158031
DOI: 10.1038/gt.2011.170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using non-coding small RNAs to develop therapies for Huntington's disease.PMID 22158031Read ↗

Delivering a disease-modifying treatment for Huntington's disease.Semantic proximity Read ↗

Progress and Challenges in RNA Interference Therapy for Huntington DiseaseSemantic proximity Read ↗

[Gene silencing approaches for the treatment of Huntington's disease].Semantic proximity Read ↗

An insight into allele-selective approaches to lowering mutant huntingtin protein for Huntington's disease treatment.Semantic proximity Read ↗

Huntington's disease: progress toward effective disease-modifying treatments and a cure.Semantic proximity Read ↗

Gene targeting techniques for Huntington's disease.Semantic proximity Read ↗

An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.Semantic proximity Read ↗

Translating Antisense Technology into a Treatment for Huntington's Disease.Semantic proximity Read ↗

Personalized gene silencing therapeutics for Huntington disease.Semantic proximity Read ↗

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.Semantic proximity Read ↗

Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.Semantic proximity Read ↗

Oligonucleotide therapeutic approaches for Huntington disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.