Article
Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2020
Hagenaars Saskia P, Coleman Jonathan R I, Choi Shing Wan, Gaspar Héléna, Adams Mark J, Howard David M, Hodgson Karen, Traylor Matthew, Air Tracy M, Andlauer Till F M, Arolt Volker, Baune Bernhard T, Binder Elisabeth B, Blackwood Douglas H R, Boomsma Dorret I, Campbell Archie, Cearns Micah, Czamara Darina, Dannlowski Udo, Domschke Katharina, de Geus Eco J C, Hamilton Steven P, Hayward Caroline, Hickie Ian B, Hottenga Jouke Jan, Ising Marcus, Jones Ian, Jones Lisa, Kutalik Zoltan, Lucae Susanne, Martin Nicholas G, Milaneschi Yuri, Mueller-Myhsok Bertram, Owen Michael J, Padmanabhan Sandosh, Penninx Brenda W J H, Pistis Giorgio, Porteous David J, Preisig Martin, Ripke Stephan, Shyn Stanley I, Sullivan Patrick F, Whitfield John B, Wray Naomi R, McIntosh Andrew M, Deary Ian J, Breen Gerome, Lewis Cathryn M
Abstract excerpt
It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression. Polygenic risk scores...
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