Article

Sex differences in the associations of genetic, sociodemographic and cardiovascular risk factors with depression in the Canadian Longitudinal Study on Aging (CLSA)

2023-04-17

Abstract excerpt

Major depressive disorder (MDD) is a leading cause of morbidity and disability worldwide, with approximately twice as many women reported to have a lifetime occurrence of MDD than men. MDD is a polygenic trait, wherein hundreds to thousands of common genetic variants with small effect sizes contribute to risk of disease. This study investigated sex differences in the risk factor comorbidity and genetic architectur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ef2b667-e4f8-50f8-80ca-aadfcda64be9
DOI: 10.1101/2023.04.10.23288267

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex differences in the associations of genetic, sociodemographic and cardiovascular risk factors with depression in the Canadian Longitudinal Study on Aging (CLSA)DOI 10.1101/2023.04.10.23288267Read

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.Semantic proximity Read

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular DiseasesSemantic proximity Read

Genetic heterogeneity affects the risk of incident depression, comorbidity, and response to environment: A prospective trajectory study.Semantic proximity Read

Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depressionSemantic proximity Read

A sex-specific genome-wide association study of depression phenotypes in UK Biobank.Semantic proximity Read

A Sex-Specific Genome-Wide Association Study of Depression Phenotypes in UK BiobankSemantic proximity Read

Causes and consequences of major depressive disorder: An encompassing Mendelian randomization studySemantic proximity Read

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.Semantic proximity Read

Clustering of major depressive disorder genetic instruments identifies distinct and directionally opposing effects on cardiometabolic riskSemantic proximity Read

Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery diseaseSemantic proximity Read

Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Semantic proximity Read

Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.Semantic proximity Read