Article

Divergent patterns of genetic overlap between severe mental disorders and metabolic markers

2024-11-04

Abstract excerpt

<h4>Background: </h4> Bipolar disorder (BIP), major depressive disorder (MDD) and schizophrenia (SCZ) are severe mental disorders (SMDs), each associated with poor cardiometabolic health. Mapping the genetic relationships of these highly heritable disorders with blood markers of metabolic activity may uncover biological pathways underlying this important shared clinical feature. Methods We charted global genetic o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9864ee7-a018-50a5-a648-84a3f0de8195
DOI: 10.1101/2024.11.04.24316693

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Divergent patterns of genetic overlap between severe mental disorders and metabolic markersDOI 10.1101/2024.11.04.24316693Read

Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexusSemantic proximity Read

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits.Semantic proximity Read

The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individualsSemantic proximity Read

Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study.Semantic proximity Read

Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits.Semantic proximity Read

Decoding the genetic crosstalk network for cardiometabolic diseases and metabolic traitsSemantic proximity Read

The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals.Semantic proximity Read

Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic DiseasesSemantic proximity Read

Mapping genetic convergence across brain structure, mental health, and cardiometabolic diseaseSemantic proximity Read

Shared genetic loci between depression and cardiometabolic traits.Semantic proximity Read

Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.Semantic proximity Read

Distinct metabolic signatures of Alzheimer’s and Parkinson’s disease revealed through genetic overlap with metabolic markersSemantic proximity Read