Unraveling the genetic interplay and therapeutic potentials between major depressive disorder and metabolic syndrome: multi-ancestry and multi-trait genome-wide association analyses.

Abstract excerpt

This investigation elucidates the genetic connection between major depressive disorder (MDD) and metabolic syndrome (MetS), suggesting bidirectional genetic correlations and shared pleiotropic genes. Leveraging a comprehensive genome-wide association study (GWAS) dataset from European and East Asian populations, we discovered new genetic markers linked to MDD and enhanced the robustness of genetic associations...

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