Article

Clustering of major depressive disorder genetic instruments identifies distinct and directionally opposing effects on cardiometabolic risk

2026-03-17

Abstract excerpt

<h4>Background: </h4> Major depressive disorder (MDD) is a highly heterogeneous condition that is frequently co-morbid with type 2 diabetes (T2D), and yet the biological mechanisms linking these diseases remain unclear. We aim to identify distinct biological pathways in depression that may modify T2D risk. Methods Using Clustered Mendelian randomisation (MR-Clust), we analysed 621 genome-wide significant MDD varia...

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Literature Corpus work: 4668732f-06b5-5ab0-8e66-5a14122cad2c
DOI: 10.64898/2026.03.16.26347391

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