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Unraveling the Genetic Interplay and Therapeutic Potentials between Major Depressive Disorder and Metabolic Syndrome: Multi-Ancestry and Multi-Trait Genome-Wide Association Analyses

2024-04-01

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<title>Abstract</title> <p>This investigation elucidates the genetic connection between major depressive disorder (MD) and metabolic syndrome (MetS), uncovering bidirectional interactions and shared pleiotropic genes. Leveraging a comprehensive genome-wide association study (GWAS) dataset from European and East Asian populations, we discovered new genetic markers linked to MD and enhanced the robustness of geneti...

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Literature Corpus work: 65b9b591-57c0-5d14-811e-d66c57e799d5
DOI: 10.21203/rs.3.rs-4193051/v1

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