Article

BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during <i>C. elegans</i> meiosis

2022-06-14

Abstract excerpt

The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote high fidelity DNA double strand break (DSB) repair, but the specific DSB repair outcomes these proteins regulate remain unknown. Here we show that BRCA1/BRC-1 and the...

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Literature Corpus work: 2c82ca6f-aa1c-582f-b1c9-ccb2c918df9f
DOI: 10.1101/2022.06.12.495837

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