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Article

Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining.

PLoS genetics - 1 Apr 2020

van Bostelen Ivo, van Schendel Robin, Romeijn Ron, Tijsterman Marcel

Abstract excerpt

Bases within DNA are frequently damaged, producing obstacles to efficient and accurate DNA replication by replicative polymerases. Translesion synthesis (TLS) polymerases, via their ability to catalyze nucleotide additions to growing DNA chains across DNA lesions, promote replication of damaged DNA, thus preventing checkpoint activation, genome instability and cell death. In this study, we used C. elegans to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32330130
DOI: 10.1371/journal.pgen.1008759
PMCID: PMC7202663

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