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Article

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.

Molecular cell - 18 Jan 2018

León-Ortiz Ana María, Panier Stephanie, Sarek Grzegorz, Vannier Jean-Baptiste, Patel Harshil, Campbell Peter J, Boulton Simon J

Abstract excerpt

Erroneous DNA repair by heterologous recombination (Ht-REC) is a potential threat to genome stability, but evidence supporting its prevalence is lacking. Here we demonstrate that recombination is possible between heterologous sequences and that it is a source of chromosomal alterations in mitotic and meiotic cells. Mechanistically, we find that the RTEL1 and HIM-6/BLM helicases and the BRCA1 homolog BRC-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29351848
DOI: 10.1016/j.molcel.2017.12.014
PMCID: PMC5783719

Genes

RTEL1
BLM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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