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Article

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres.

Chemical communications (Cambridge, England) - 7 Aug 2020

Zhu Min, Yu Yanyan, Zhu Junfeng, Zhou Yao, Su Gaoxing, Zhu Hongyan, Chen Yong, Liu Mingkai

Abstract excerpt

Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

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Identifiers

PMID: 32678380
DOI: 10.1039/d0cc03425h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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