Dual Confinement-Enhanced Multiple Single Nucleotide Variant Detection at the Single-Particle Level.

Abstract excerpt

The efficacy of multiple single nucleotide variants (SNVs) analysis is far from ideal due to the limitations in identification. This study introduced a novel strategy for multiple SNVs analysis at the single particle level, integrating molecular and nanomaterial confinement to significantly accelerate the kinetics of multiplex recognition processes. Leveraging DNA tetrahedra to enhance sample background...

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• DNA
• Gold
• Machine Learning
• Metal Nanoparticles
• Nucleic Acid Hybridization