Article
Loop Site Mutation-Enhanced Sensing Performance of G-Triplex Probe: Preliminary Exploration on Its Stability and "Structure-Efficiency" Relationship.
Analytical chemistry - 19 Aug 2025
Zhou Hui, Huang Feng, Xie Yingyan, Tan Bo, Wang Yuhong, Fu Danzhi, Wang Wei, Qiu Zijie, An Huihua, Liu Yan, Zhou Yubin
Abstract excerpt
G-triplex is a unique topological structure formed by G-rich nucleic acid sequences with three G-tracts. It can bind to small ligands and function as a label-free sensing probe. However, the number of discovered G-triplex/small ligands with stable structures and excellent performance is still limited, requiring deeper insight on their "structure-efficiency" relationships. In this paper, we systematically...
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