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Precise Conformational Tuning Facilitated by Tetrahedral DNA Framework Dimers for Enhanced Biomolecular Detection.

Analytical chemistry - 15 Apr 2025

Jin Jiankai, Qin Guoqian, Nie You, Wu Yi, Zhang Jun, Zuo Xiaolei, Hao Rongzhang, Wang Shaopeng

Abstract excerpt

Cellular systems achieve precise biomolecular recognition through dynamic regulation of molecular conformation and spatial arrangement, a complexity that is difficult to replicate in vitro, limiting advancements in biosensing technologies. The nanoscale programmability of tetrahedral DNA frameworks (TDFs) offers a compelling solution, enabling precise control over the spatial arrangement and conformation of...

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PMID: 40167383
DOI: 10.1021/acs.analchem.5c00860

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IDH1
MAF

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