Article
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments.
Molecular neurodegeneration - 16 Jul 2020
Kaniyappan Senthilvelrajan, Tepper Katharina, Biernat Jacek, Chandupatla Ram Reddy, Hübschmann Sabrina, Irsen Stephan, Bicher Sandra, Klatt Christoph, Mandelkow Eva-Maria, Mandelkow Eckhard
Abstract excerpt
Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau pathology in AD by templated conversion of naive Tau in recipient cells into a pathological state, followed by...
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