Article

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau fibers

2020-03-25

Abstract excerpt

Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau pathology in AD by templated conversion of naive Tau in recipient cells into a pathological state, followed by assemb...

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Literature Corpus work: b2fb6d15-03ff-5e46-9d84-c60e88f780dc
DOI: 10.1101/2020.03.25.998831

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